Key Factors
  • Enterotoxigenic Escherichia coli (E. coli) is the most common cause of diarrhoeal episodes globally.
  • Repeat infections are associated with growth faltering.
  • ETEC is one of the leading causes of death occurring due to diarrhoeal infections mostly under the age of 5. The global disease burden of ETEC reflects high mortality and morbidity rates which indicate towards the need for developing vaccines.
  • Currently there is no marketed vaccine for ETEC.
  • ETEC is estimated to cause
    • ~22,000 deaths in young children Under 5 and ~60,000 deaths among all ages
    • ~84 million ETEC episodes among all ages
    • 3.1 million DALYs
  • Based on the application of more sensitive detection methods, there is likely a significant underestimation of the true impact of ETEC on child and traveller health.
  • ETEC comes under the list of Top 10 Enteric diarrhoeal diseases.

Ref: 1. D. Steele. Bacterial Enteric Pathogens : ETEC & Shigella, BMGF 2. WHO PDVAC 2018. Status of vaccine development for ETEC 3)

Source: Troeger, C., Forouzanfar, M., Rao, P.C., Khalil, I., Brown, A., Reiner Jr, R.C., Fullman, N., Thompson, R.L., Abajobir, A., Ahmed, M. and Alemayohu, M.A., 2017. Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet Infectious Diseases, 17(9), pp.909-948.

  • ETEC is one of the leading causes of traveller’s Diarrhoea.
  • Annually about 64 million people travel from developed to LMIC and developing countries.
  • Each year 22 million travelers suffer from Diarrhoea mostly when they visit LMIC.
  • 45% of these Diarrhoea cases are attributable to ETEC, i.e. about 10 million travellers worldwide suffer from ETEC induced Diarrhoea.
  • The major reason for high prevalence in LMIC and developing countries is poor sanitation and weak health care infrastructure.