Microarray Patch

HILLEMAN LABORATORIES IS WORKING TO ADVANCE MAPs AS VACCINE DELIVERY TECHNOLOGY PLATFORM FOR HIGH PRIORITY NEEDS IN LOW INCOME COUNTRIES (LIC)/LOW & MIDDLE INCOME COUNTRIES (LMICs)

  • Working on MAP delivery technology, exclusively with a technology partner for optimization and clinical evaluation work on vaccines/adjuvants.
  • Our microarray patch is a customizable array of dissolvable micro-sized needles with drug/vaccine encapsulated within a biocompatible polymeric matrix for skin delivery.
Key Features
  • A versatile platform technology with pre-clinical proof of concept established on various vaccine antigens.
  • Scalable moulding fabrication method, with active loading at the tip of the microneedle, to enhance penetration & complete delivery.
  • Technology with high active loading capability of up to 1 mg solid and 0.5 mL liquid.
  • Potential of dose sparing, increased stability, superior compliance.
  • Simplified logistics, simple applicator and packaging design with minimal application time and quick dissolution.
Problem

Diseases in LMIC can be eradicated but current levels of vaccination coverage has been stagnated due to

  • Safety of reconstitution and administration.
  • Stringent cold chain requirements.
  • Difficulty in door to door vaccination campaigns.
  • Complex handling, time for administration and availability of trained health care workers.
  • Vaccine hesitancy and wastage, lower acceptability.
  • Medical waste disposal.
Need

Improved presentations of vaccines and pharmaceuticals in low and middle income countries.

“MICROARRAY PATCHES” as a transformative tool:
  • Enable alternative delivery scenarios---increasing coverage and equity.
  • Enhance immunogenicity of existing/novel vaccines.
  • Improve adherence to dosing regimens.
  • Reduce burden on health systems.
  • Vaccine hesitancy and wastage, lower acceptability.
  • Medical waste disposal.